Neural ageing, made measurable.

“A single gap figure is easy to dismiss. A report that shows which structures carry the deviation — and where the model’s attention concentrates — gives our readers something concrete to examine.”

“In cohort work, the measure you track has to be defined the same way at every site and every visit. An age-normalized brain-age slope from one fixed pipeline is the clearest candidate we have for that role.”

“Ageing on a scan is something we read subjectively — two experienced readers rarely land on the same number. One calibrated pipeline replaces that quiet disagreement with a defined figure and an interval you can actually discuss.”

“In multi-centre imaging, most of the debate sits in everything around the model — protocols, motion, corrections. Automated preparation to one common space takes most of that off the table before the estimate is even computed.”

“Our scans span a decade and several scanner generations. A downstream measure that is computed the same way for every scan is really the only way those years stay comparable within one person.”

“Families always ask what the scan actually tells them. A structured report — one number for the gap, named regions below it — is much easier to explain honestly than an overall impression.”